منابع مشابه
Finding Motifs in Promoter Regions
A central issue in molecular biology is understanding the regulatory mechanisms that control gene expression. The availability of whole genome sequences opens the way for computational methods to search for the key elements in transcription regulation. These include methods for discovering the binding sites of DNA-binding proteins, such as transcription factors. A common representation of trans...
متن کاملFinding Motifs with Gaps
This paper focuses on a set of string pattern-matching problems that arise in musical analysis, and especially in musical information retrieval. A musical score can be viewed as a string: at a very rudimentary level, the alphabet could simply be the set of notes in the chromatic or diatonic notation, or the set of intervals that appear between notes (e.g. pitch may be represented as MIDI number...
متن کاملFinding Regulatory Motifs
The most efficient step for gene regulation is transcription, i.e., the copy of DNA of a gene to mRNA molecule that ultimately is translated to a protein. Transcription is controlled in the promoter by a set of transcription factor binding sites (TFBSs). These TFBSs recruit transcription factors (TFs) that facilitates the allocation of the transcription machinery and, therefore, increase the pr...
متن کاملA New Exhaustive Method and Strategy for Finding Motifs in ChIP-Enriched Regions
ChIP-seq, which combines chromatin immunoprecipitation (ChIP) with next-generation parallel sequencing, allows for the genome-wide identification of protein-DNA interactions. This technology poses new challenges for the development of novel motif-finding algorithms and methods for determining exact protein-DNA binding sites from ChIP-enriched sequencing data. State-of-the-art heuristic, exhaust...
متن کامل[Biological functions of the duplicated GGAA-motifs in various human promoter regions].
Transcription is one of the most fundamental cellular functions and is an enzyme-complex mediated reaction that converts DNA sequences into mRNA. TATA-box is known to be an important motif for transcription. However, there are majority of promoters that have no TATA-box. They are called as TATA-less promoters and possess other elements that determine the transcription start site (TSS) of the ge...
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ژورنال
عنوان ژورنال: Journal of Computational Biology
سال: 2005
ISSN: 1066-5277,1557-8666
DOI: 10.1089/cmb.2005.12.314